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The data presented in Table 2 and visualized in Figure 2 (Comparative Analysis of the ADC Global Landscape) and Figure 3 (The Path to First Approval) demonstrate a significant clinical disparity
The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: The Age-Related Eye Disease Study Report Number 6

The early rationale behind this was that it placed the regulatory programs where there was comparable existing expertise
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doi: 10.1080/10717544.2017.1402220 182 CenJDaiXZhaoHLiXHuXWuJet al