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With the methoxy substitution, an analog of 36 , reduces potency to IC 50 value of 40.02 M, suggesting that hydrogen bond interactions were favorable than the hydrophobic interactions provided by methoxide groups
[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Moreira A, Lawson D, Onyekuru L, Dziemidowicz K, Angkawinitwong U, Costa PF, et al
Neurology 85 , 16701679 (2015)
