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Description
This interaction triggers the assembly of a signaling complex that includes interleukin-1 receptor-associated kinases and TNF receptor-associated factor 6, leading to the activation of nuclear factor kappa B (NF-B) and mitogen-activated protein kinases (MAPKs) such as p38 and JNK [128]
Philip Pape: 13:35 Don't know what caused it
HER2-directed therapy: current treatment options for HER2-positive breast cancer
Though human studies are lacking, preclinical trials support its potential in treating fractures

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