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In very rare cases, people who are sensitive or allergic to cobalt may experience skin reactions, especially after high-dose B12 injections

Vitamin B12 requires a complex absorption process involving intrinsic factor and stomach digestion of ingested B12 (we will get to why this is relevant towards the end of this article)

Exceptional Cases to Avoid Shots People with kidney problems, iron deficiencies, or known sensitivities/allergies to vitamin B12 should not get B12 injections since side effects could be more likely

With guidance from a licensed provider, B12 injections are safe for regular use

Unlike a broken bone that follows a predictable recovery arc, shoulder soft tissue injuries often linger for months or even years