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For the acute model, it is important to note that in contrast to humans, the initial immune response decreases significantly within 30 days, and MPTP-injected mice may recover over time (203)
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Animal models: To analyse the possible role of CBS in Down syndrome, there are several lines of transgenic mice expressing the human CBS gene described in Herault et al, Disease Models & Mechanisms 2017
How reactive metabolites induce an immune response that sometimes leads to an idiosyncratic drug reaction
Huang J, Agus DB, Winfree CJ, Kiss S, Mack WJ, McTaggart RA, Choudhri TF, Kim LJ, Mocco J, Pinsky DJ, Fox WD, Israel RJ, Boyd TA, Golde DW, Connolly ES: Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke
