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The majority of alcohol is oxidized in the cytosol by aldehyde dehydrogenase (ADH), in peroxisomes by CAT, and in microsomes and mitochondria by CYP2E1 via the microsomal ethanol-oxidizing system (MEOS) before toxic acetaldehyde is further detoxified by mitochondrial aldehyde dehydrogenase 2 (ALDH2) [187, 188]