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Perhaps most significantly, epigenetic modifications including DNA methylation alterations, histone modifications, and non-coding RNA dysregulation create molecular signatures that contribute to transgenerational inheritance of reproductive dysfunction

Yes, it's usually a normal reaction

Costs may come down or future development of new markers or selective agents may help to address this concern, but it should also be borne in mind that while the GSH feedback system was convenient for proof of principle in this study, the door is open to explore other regulatory systems of yeast which may prove more efficacious for enrichment of high-producing individuals including, potentially, for commercial exploitation

doi: 10.1179/1351000213y.0000000068 77 SalminenW