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Hill MH, Flatley JE, Barker ME, et al

doi: 10.1111/and.13644 71 MajzoubAAgarwalA

Naringenin has been shown to restore the estrous cycle and reduce pro-inflammatory cytokines like IL-6 and TNF- in PCOS rats [127]

However, it does not correct the underlying cystic fibrosis transmembrane conductance regulator defect, as shown by the lack of improvement in nasal transepithelial potential difference in cystic fibrosis transmembrane conductance regulator-deficient mice, indicating that epithelial ion transport remains impaired

Due to the strong cytoprotective effects of GSH, alterations in GSH homeostasis have been associated with neurodegenerative diseases, AIDS, liver and heart disease, aging, diabetes mellitus and cancer (reviewed in [19,20,21])