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In the SOD1 G93A rat model, Nrf2 levels of astrocytes at the onset of ALS were found to be higher than basal levels in controls (Vargas et al
& Parker, M
They are water-soluble and function in the cytoplasm and mitochondria [47,76-79]
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This finding is strongly supported by additional research confirming that NF-B and MAPK activation are the underlying mechanisms for the immuno-enhancement observed with BSP treatment
