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In addition, it has been shown that when the ferroptosis inducer imidazole ketone erastin (IKE), SOR and cytoplasmic proton radiation act synergistically, tumor killing is significantly enhanced in mouse xenograft models and human patient-derived lung adenocarcinoma models [199]

10.1155/2016/6432867 149 TianQ.WuS.DaiZ.YangJ.ZhengJ.ZhengQ.et al (2016)

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There is a positive feedback loop between p62 and Nrf2: p62 is a target gene for Nrf2, promoting Nrf2 stimulation and Nrf2 promotes p62 production ( Keap1-independent Mechanism of Nrf2 Regulation Although the majority of Nrf2 is mainly moderated by Keap1 in answer to ROS/electrophiles, some researchers found that the PI3K-AKT signaling pathway could also stimulate Nrf2 (Figure 1) (Martin et al., 2004