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doi: 10.1016/j.cell.2025.02.009 Summary Keywords antiretroviral therapy, cGAS-STING, HIV, immunometabolism, inflammaging, mtDNA, oxidative stress Citation Ma L, Wang X and Xu H (2026) Mitochondrial DNA damage in HIV infection: a mechanistic driver of immunometabolic dysfunction and chronic inflammation

Importantly, these patients do not exhibit severe immunodeficiency ( This unique clinical phenotype strongly supports DPP1 inhibition strategy feasibility, indicating that even with severely reduced NSP activity, overall immune defense function can remain essentially intact

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