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In human cancer cell studies or in vivo models (hepatocellular, breast, lung, and others), OA and its derivatives significantly inhibited the carcinogenesis, reduced the growth and proliferation of cancer cells, induced their apoptosis, showed cytotoxic effects, or inhibited angiogenesis, invasion, and metastasis [279,280,281,282,283,284,285,286,287,288,289,290,291,292]

10.1074/JBC.272.1.154 99 PanahiY.SahebkarA.AmiriM.DavoudiS

Shikonin induces glioma cell necroptosis in vitro by ROS overproduction and promoting RIP1/RIP3 necrosome formation

(2019) 7:e126979

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