melatonin and glutathione peroxidase The effects of on (GPx) activity in Melatonin—A Powerful Antioxidant in Neurodegenerative

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(2023) 31:102137.e10

Use binders like activated charcoal or bentonite clay to absorb toxins

Additionally, a study demonstrated how dietary cocoa administration was able to raise the levels of several peptides in the blood that have anti-inflammatory and anti-nociceptive properties, while at the same time inhibiting the expression of pro-phlogogenic proteins and neuronal sensitization to reduce inflammation (Feo et al., 2020)

Additionally, the increase in hemichannel activation due to an increase in pro-inflammatory cytokines [e.g., tumor necrosis factor- (TNF-) and interleukin-1 (IL-1)] in primary cell cultures and mice results in an increase in the release of various ions (i.e., K + , Ca 2+ ) and gliotransmitters (i.e., ATP, glutamate) into the extracellular space, further disrupting homeostasis and possibly contributing to neuronal death (Retamal et al., 2007