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The gut-skin axis highlights how imbalances in the microbiome can trigger inflammation, potentially worsening autoimmune skin diseases like vitiligo

Mechanisms include: Increased oxidative stress Glutathione depletion Mitochondrial toxicity Induction of liver detox enzymes Importantly, GGT can rise even with moderate, socially acceptable alcohol intake , especially in genetically susceptible individuals

Jung CH, Ahn J, Jeon TI, Kim TW, Ha TY

The role of metformin in the management of NAFLD
