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Proteinligand interactions, including hydrogen bonds (distance cutoff 3.5 , angle 120), hydrophobic contacts, and -stacking interactions, were analyzed and visualized using PyMOL 2.5 (Schrdinger, 2023)

138 , 25012504 e2501 (2018)

*Correspondence: Toshihiko Aki [email protected] Specialty section: This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Larger, well-controlled studies are still needed to confirm whether these effects are consistent, to whom they apply, and which dosing approaches are most appropriate

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