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This will be more comfortable Keep the needle still while injecting to avoid snapping it Further Information For further advice and information about your condition, please choose from the following: NHS Patient Choices website: www.nhs.uk Making Lives Better patient website: www.patient.info Telephone NHS 111 Contact your General Practitioner Contact details The James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW Telephone: 01642 850850 The Friarage, Northallerton, North Yorkshire, DL6 1JG Telephone: 01609 779911 Redcar Primary Care Hospital, West Dyke Road, Redcar, TS10 4NW Telephone: 01642 511000 If you have any medical concerns or need advice please contact 111, for further information regarding this leaflet please contact: [email protected] This email will be monitored 9am until 4pm Monday to Friday

In an attempt to assess the impact of this fortification, Brito and colleagues (29) assessed the effect of a single intramuscular injection of 10 mg vitamin B-12 (plus 100 mg vitamin B-6 and 100 mg thiamin) in 51 Chilean asymptomatic vitamin B-12deficient older adults on changes in vitamin B-12 status determined by a combinedvitamin B-12 (c-B12) index, a calculated measure that combines the 4 blood biomarkers of vitamin B-12 status: total vitamin B-12, holotranscobalamin (holoTC), tHcy, and MMA (48)