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The role of oxidative stress in the COVID-19 disease may involve recognition of the viral S-protein by angiotensin converting enzyme-2 (ACE2) receptor and pattern recognition receptors like toll-like receptors 2 and 4, and activation of transcription factors like nuclear factor kappa B, that subsequently activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) expression succeeded by ROS production (Kozlov et al., 2021)

Acute lower respiratory infection among Bacille Calmette-Gurin (BCG)-vaccinated children

Additionally, it may have potentially lowered the expression of urea cycle enzymes, restored nitrogen balance, and hypothetically normalized or improved the nitrogen contents in organs

Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ

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