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[DOI] [PMC free article] [PubMed] [Google Scholar] 85.Bullard B.M., VanderVeen B.N., McDonald S.J., Cardaci T.D., Murphy E.A

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Oct 13 : Pfizers $6.7 billion acquisition of Arena Pharmaceuticals paid off in a big way Friday as the FDA approved etrasimod to treat moderate to severe ulcerative colitis (UC)

I n skeletal muscle, IGF1R activation sensitizes IRS1 to degradation, and a screen for the responsible E3 ligase identified Fbxo40 as mediating this rapid turnover of IRS1, since IRS1 loss can be rescued by knockdown of Fbxo40

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