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Particular focus should be placed on interactions between mHTT, the ironmetabolism axis (such as transferrin receptor 1 and hepcidin), and key ferroptosis mediators (GPX4 and Nrf2) to build a dynamic model linking mHTT aggregation, iron dysregulation, and neuronal ferroptosis, and to define subtype-specific vulnerability of MSNs

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doi: 10.1016/s0140-6736(86)92134-3

Aged garlic extract appears to be the most consistently effective because it stabilizes these compounds and reduces the GI side effects some people experience with raw garlic

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