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Clinical Safety Profile BPC-157 has been shown to have no significant adverse effects on organ systems in multiple preclinical studieseven when administered in supra-physiological doses

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However, in a randomized phase III double-blind clinical trial, tivantinib did not improve OS time in patients with Met-high advanced HCC treated with sorafenib compared with placebo (Rimassa et al., 2018) (NCT01755767)