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Significant efficacy of a low dosage of Pycnogenol (60 mg daily) on climacteric symptoms could be shown in an RDP investigation with 170 women (47)

However, in cultures of the SEV group, the reduction of CCL3 by B12 did not reach statistical significance and intracellular IL-1B levels were very low, close to the detection limit of the technique, suggesting that, in severe COVID-19, leukocytes are more prone to promptly export IL-1B

doi:10.2174/1381612826666200424180139 Park JM, Lee HJ, Sikiric P, Hahm KB

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[DOI] [PubMed] [Google Scholar] 174
