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10.1038/s41598-021-00792-8 53 FarrantM.NusserZ

HOCl-modified HSA can thus be considered a pro-inflammatory mediator, that together with other inflammatory stimuli, such as cytokines, PAMPs or DAMPs, extends neutrophil lifespan at sites of tissue injury and inflammation through the inhibition of cell apoptosis [45,46,47] (Fig

603 Loss of any one of these results in ichthyosis in humans while the gene knockout in mice has a neonatal lethal phenotype