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Natl Med

Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer

( Radioligand access to brain is modified by general metabolism, which can differ across cases and controls One common theory of ME/CFS is that it is, at root, a disorder of mitochondrial dysfunction and reduced metabolism [e.g., ( Activated peripheral immune cells bind radioligand and can differ in quantity across cases and controls While PBR28 has improved non-specific binding, the antigen that it binds to can occur in non-target tissues and in blood

Lenz H, Prenen H, Cutsem EV, Kssler T, Mayol J, Trapani F, Tihy M, Rubbia-Brandt L, Toso C, Bogenrieder T, Belnoue E, Derouazi M, Kopetz S

Mechanistically, bacterial flagellin induces a proinflammatory response by activating Toll-like receptor-5 (TLR5) in macrophages, and the presence of flagellin antibodies in pancreatic biopsies of individuals with type 2 diabetes lends support to this mechanism in humans