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End Stage Renal Disease (ESRD) patients on maintenance hemodialysis may have low plasma carnitine concentrations and an increased ratio of acylcarnitine/carnitine because of reduced intake of meat and dairy products, reduced renal synthesis and dialytic losses

The therapy helps with swelling and pain often seen after such procedures

Nature 399:362366 Hu Q, DAmora DR, MacNeil LT, Walhout AJM, Kubiseski TJ (2018) The Caenorhabditis elegans oxidative stress response requires the NHR-49 transcription factor

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This might be due to the heterogenicity in the study materials from ME/CFS patients, different severity of the disease, prior infections and medication history of the patients