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The detailed description of the protocol used as well as demographic and clinical characteristics of participants have been described in a separate study previously published ( To further assess the effect of NAC treatment in modulating host immune response, we measured the concentration of several cytokines, chemokines, growth factors and lipid mediators in plasma isolated from patients receiving or not NAC at the study baseline and day 60 of treatment (see Methods for details in the choice of the parameters)

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Commonly followed approach hai 3-month daily cycle, uske baad 2-4 week ka break

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Treatments administered to primary AML cells included oridonin, orid-liposome, orid-liposome-MAL, and TLR2 pep-orid-liposome, each at a concentration of 4 M