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Vitamin B12 deficiencies due to malabsorption which may be associated with the following conditions

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StatPearls [Internet], 2023 June Takaaki Sugihara, Masahiko Koda, Toshiaki Okamoto, Kenichi Miyoshi, Tomomitsu Matono, Kenji Oyama, Keiko Hosho, Jun-ichi Okano, Hajime Isomoto, Yoshikazu Murawaki

Typically, people who have had gastric surgery and whose bodies have difficulty absorbing vitamin B12 receive injections or infusions

A clinically meaningful response in the 30, 49 age group typically means a 2 to 4% reduction in body fat mass or a measurable decrease in waist circumference over 8 to 12 weeks, based on the weight-loss trajectory data from GLP-1 comparator trials such as STEP-1 (N=1,961), where semaglutide 2.4 mg produced a 14.9% mean weight loss at 68 weeks [10]