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The intrinsic factor then binds with B12, facilitating the uptake of B12 in the small intestines.[ref] Without intrinsic factor, you cant absorb B12 from animal proteins

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Concurrently, there is a downregulation in the expression of components of voltage-gated potassium channels, which normally regulate neuronal excitability, repolarization, and frequency of action potentials
Hepatology 71 , 16091625 (2020)

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