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Many studies have shown that LA treatment ameliorates plasma triglycerides (TG), oxidative stress, and hepatic fat accumulation (Table 2) in young and aged animals fed normal diets

534 HODEs are also reported activators of the TRPV1, but their importance as endogenous regulators of TRPV1-dependent physiology (e.g., nociception) is still debated

The challenges included demonstrating the circadian rhythm of the drug target, creating a drug formulation that replicated that rhythm and then proving benefit in clinical trials

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In clinical studies in patients with interferon alfa-refractory hairy cell leukemia, a complete response to pentostatin therapy generally was defined as clearing of peripheral blood and bone marrow of hairy cells