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The analysis of the gdh2 / gdh2 and the gdh3 / gdh3 mutants confirmed our hypothesis that redox potential and nitrogen metabolism are related to filament formation and identified these metabolic pathways as potential drug targets to inhibit morphogenesis

Final Takeaway Oxidative stress is unavoidable, but that doesnt mean you have to let it take control

On the other hand, a more recent study from 2015 found that beta-arbutin is more effective both on mouse melanoma cells and on human melanoma cells (btw, kojic acid was the most effective on human melanoma cells)

Zhou LY, Mo G, Wang S, Tang JF, Yue H, Huang LQ, Shao AJ, Guo LP (2014) [Stability analysis of reference gene based on real-time PCR in Artemisia annua under cadmium treatment]