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Smith M, De Bono J, Sternberg C, Le Moulec S, Oudard S, De Giorgi U, et al

It is hoped that this manuscript will appeal to a wide readership audience that includes clinicians caring for patients, researchers, regulators, pharmaceutical industries sponsoring drug trials, and patients for whom these drugs are intended

This helps explain why identical twins can have differing disease patterns

Second, as all analyses were exploratory, and the primary analysis for each endpoint was specified, multiple comparisons were performed only without P value correction