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These cells remain sequestered in the dermis for months to years, where the Tyndall effect translates deep-seated pigment into a clinically characteristic gray-blue hue [156]

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In severe cases where preventive strategies are ineffective or in case of significant limitations in the patient's quality of life, omalizumab can be a beneficial addition, as demonstrated in this case report

The comparison between MOTS-c vs AOD9604 reveals different mechanisms MOTS-c works mainly by improving mitochondrial function and insulin sensitivity, while AOD9604 directly stimulates lipolysis