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Because they work on a cellular level, a "more is better" approach doesn't apply here

Patients with pernicious anaemia, malabsorption disorders (such as Crohn's disease or coeliac disease), or following gastric surgery require regular B12 supplementation to prevent serious complications including megaloblastic anaemia and neurological damage

M.SankarasubramanianJ.JoshiV.ElkhatibS

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Emerging evidence indicates a mechanistic interplay between the Nrf2Keap1 axis and the NLRP3 inflammasome, wherein Nrf2 activation not only counteracts oxidative stress but also suppresses NLRP3-mediated inflammatory signaling