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Acute injuries may respond in 4-6 weeks

doi: 10.1104/pp.105.062000

Stimulants cause tolerance development, meaning increasing doses are needed for the same effect

doi: 10.1001/jama.294.7.813

While toxicity is rare, excessive intake of certain B vitamins (particularly B or B) from multiple sources could increase the risk of side effects (like niacin flush or peripheral neuropathy)
