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Heat-responsive and time-resolved transcriptome and metabolome analyses of Escherichia coli uncover thermo-tolerant mechanisms

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One promising avenue of research may be to explore derivatives of N-acetylcysteine such as N-acetylcysteine amide, which has been reported in preclinical studies to have higher permeability through cellular and mitochondrial membranes with increased central nervous system bioavailability compared to N-acetylcysteine

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Although ketones are not actively utilized by the liver, due to low level expression of the mitochondrially-localized enzyme encoded by the OXCT1 gene, cytosolic acetoacetate can contribute to de novo lipogenesis in the liver through the actions of the AACS and ACAT2 encoded enzymes