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An in-vitro study showed that IL-10 mRNA expression was highly downregulated by NAC, resulting in the suppression of the proliferation of inflammation cascades (7, 8)

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Because the polarized-M2 phenotype of macrophages affects tumor growth, invasiveness, angiogenesis (140), and GSK 3 has been reported to enhance the polarization of microglia toward M2 (141), GSK 3 may be the potential therapeutic target for cancer immunotherapy

doi: 10.1038/srep44659

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