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however also serve as critical intracellular messengers modulating cell survival adaptive responses and pathways (40)

A volume of 350 L of 0.1 M potassium phosphate buffer (pH 7.4), 50 L of 1 mM substrate (diclofenac for CYP2C9 assay and dextromethorphan for CYP2D6, both substrates purchased from Sigma-Aldrich, USA) and 50 L of 2.5 mg/mL microsome (obtained from rat livers from respective groups) were mixed separately in Eppendorf tubes

Accordingly, functional studies and chemoproteomics have demonstrated substantial overlap in the mechanism of action of artemisinin and ozonide compounds, consistent with a shared heme-dependent activation and overlapping target profile ( 18 , 3032 )

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Daily Fluid Intake Most people should aim to drink enough during the day so their pee is a clear pale yellow colour