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These metabolic benefits translate into whole-body effects: for example, in diet-induced obesity models, MOTS-c administration prevented excessive weight gain and insulin resistance when mice were fed a high-fat diet, without affecting weight in lean diets

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A muscle-restricted IGF-1 transgene preserved regenerative capacity in aging mouse muscle without the pathology of whole-body overexpression, and humans lacking the circulating ternary complex still grow nearly normally on local tissue IGF-1

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