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Here, we review available clinical trials and show the disruptive effect of antibiotic use on the gut microbiome in humans, as well as its impact on bile acid metabolism and microbial metabolites such as short-chain fatty acids

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The ESC consensus statement on inflammation in atherosclerosis concludes that CRP determination is not advised as it adds little value to the existing methods of cardiovascular risk assessment.88 Persistent elevation of hs-CRP despite adequate control of LDL-C has been shown to indicate the presence of RIR, but the absence of clinical pharmacology studies demonstrating a reduction in events with exclusively anti-inflammatory drugs has restricted the generalisation of the determination of hs-CRP in patients with CAD

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MT-II has been the subject of repeated public regulator warnings (TGA, MHRA, FDA, EMA) over illegal sales and risks