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Drop one dose level every 4 weeks (for example, from 10mg to 7.5mg to 5mg to 2.5mg)

While two of the four dogs had an estimated MRT within 0.2 hours (10.4 & 10.6 hrs), the MRT of the other two dogs was significantly less (3.1 & 1.3 hrs).[51, 52] Whether the MRT calculated in this study is due to the low rapamycin dose utilized, the intermittent dosing schedule, the duration of administration, or a combination of these factors, is unknown

doi: 10.1186/1364-8535-16-R32

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Statements Author contributions MM: Data curation, Funding acquisition, Methodology, Writing original draft, Writing review and editing