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found that sequential application of ATRA, RIF, and chemotherapy shows better efficacy and less toxicity, especially for high-risk patients [128]
Moreover, an increasing body of information highlights the various protective mechanisms of butyrate against the development of CRC

SAMe, a methionine derivative, is critical for the synthesis of nucleic acids, proteins, and phospholipids (compounds necessary for recovery after an acetaminophen overdose)

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It could potentially make these less effective or cause unpredictable fluctuation