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These phenotypic differences lie in single amino acid changes that greatly affect the structure and therefore binding affinity of ApoE, with ApoE3 containing Cys-112 and Arg-158, ApoE2 having Cys-112 and Cys-158, and finally ApoE4 with Arg-112 and Arg-158 (Huang and Mahley, 2014)

Journal of Economic Literature

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The frequency depends on your specific situation some people start with weekly shots and then move to monthly maintenance doses once their levels stabilize