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These data support the calculation of the Maximum Recommended Starting Dose (MRSD) the starting dose for the first administration in humans, derived from preclinical data and converted to a human equivalent dose using internationally agreed methods

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These results were compared to the control group treated with TNF-alpha, an activator of caspase-dependent apoptosis, thus inducing strong activation of both caspases and indicating the induction of apoptosis in the cells

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