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doi: 10.3389/fcell.2025.1719332 Received 06 October 2025 Revised 17 November 2025 Accepted 19 November 2025 Published 10 December 2025 Volume 13 - 2025 Edited by Liang Ma, Huazhong University of Science and Technology, China Reviewed by Yu Han, Shanghai Jiao Tong University, China Liang Kang, First Affiliated Hospital of Anhui Medical University, China Yongzhi Cui, Shanghai Jiao Tong University, China Updates Copyright 2025 Wang, Xu, Hua, Mao, Zhang, Ma and Lu

It is essential for the initial transport of activated long-chain fatty acids across the mitochondrial membrane via the CPT system, thus governing the substrate flux available for both -oxidation and subsequent ketogenesis