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A dose-dependent regulation of cellular signal pathways by 4-HNEs has been demonstrated: at concentrations above 10 M, 4-HNEs exerted cytotoxic effect, while at concentrations below 10 M (physiological range) 4-HNEs modulated cell growth, i.e

Post-mortem studies of the autistic brain samples showed abnormal changes in the steady-state levels of complexes I-IV in the cingulate gyrus, cerebellum, thalamus, and temporal and frontal cortex [79, 80, 86, 122]

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