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Permanent activation of Nrf2 by the genetic knockout of its negative regulator KEAP1 is extremely unfavorable for the organism: newborn knockout mice die quickly from starvation, most likely due to increased expression of -keratins and subsequent gastrointestinal keratosis [88]

Glutathione Glutathione is a natural antioxidant in human cells that helps neutralize free radicals, boost the immune system, and detoxify your body

[DOI] [PMC free article] [PubMed] [Google Scholar] 241.ivani M, Espona-Noguera A, Lin A, Canal C

Liu J, Shen JX, Wen XF, Guo YX, Zhang GJ

[DOI] [PubMed] [Google Scholar] 123.Math A.A., Michaneck M., Berg E., Charney D.S., Murrough J.W