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In HeLa tumor-bearing mice, drug cytotoxicity was significantly increased and tumor hypoxia was enhanced

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For this reason, MEL and its metabolites may serve as effective therapeutic agents in iron-induced oxidative stress, for example, in patients with Parkinsons and Alzheimers disease, in whom higher levels of iron and lipid peroxidation have been observed in the brain compared to healthy individuals [76,77]

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