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Noninsulin antidiabetic drugs for patients with type 2 diabetes mellitus: are we respecting their contraindications

Scofield MD, Kalivas PW

Retina (Philadelphia, Pa) 2016;36(1):148155
any adjustments to escalation schedules would be protocol-specific and determined by the trial clinician, as established dose-modification data for retatrutide are not yet available

And what we are finding out today is that there's a very small subset of people, maybe 5 or 10% of the population, they have as they age, they have this gene mutation where either they cannot produce glutathione or the needs are very high
