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1 In the absence of adequate GSH concentrations, numerous oxidative and nitrosative reactive intermediates persist, including superoxide, hydroxide, peroxide, and peroxynitrite radicals, which all can lead to modification of cellular macromolecules including lipid membranes (measured in vivo by F2-isoprostanes) and DNA adduct formation (measured in vivo by 8-hydroxy-2-deoxyguanosine [8-OHdG])

Johnsen, S

One main reason is the difference between controlled lab models and the complex reality of human heart disease

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As I mentioned above, this metabolism of alcohol depletes glutathione levels in the body, the liver's main antioxidant