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First, monothiol Grxs (active site sequence CXXS) cannot deglutathionylate target proteins

10.1016/j.neubiorev.2020.10.004 [DOI] [PubMed] [Google Scholar] Block M
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The number of people with diabetes is expected to increase from 537 to783 million over the next 24 years causing a rise in global DN prevalence (Tuttle et al., 2022)
