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The enzyme is translated as a single polypeptide chain and autocleaves into two subunits that remain noncovalently bound to each other (Kinlough et al., 2005, Nash and Tate, 1982, West and Hanigan, 2010)

About 30% of cases are resistant to pharmacological treatment, classifying them as Treatment-Resistant Depression (TRD) [92]

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However, when confronted with the challenges associated with solid tumors, CAR-T cells have increasingly exhibited limitations, including inadequate infiltration and a shortened lifespan

Review paper: absorbable polymeric surgical sutures: chemistry, production, properties, biodegradability, and performance